More on Ms. Fruit Fly and Boy Is It Fun

Never any lack of entertainment value when Palin opens her mouth. She is a walking, talking Saturday Night Live Meets Barbarella v. The Three Stooges.

But let's get to the mighty fruit fly (and again, this is dedicated to our friend, IT).

I talked about this the other day, here.

Enter Keith Olbermann. His topic on fruit fly begins at 1:40 (in the video below). Then Olbermann shifts to Michelle Obama and her talk about Obama's grandmother, Toot, who is seriously ill. Michelle thanks the public for their notes of concern, support and prayers for Toot and their family. She is graceful, kind and thoughtful (and made this ol dog cry). I can see the weight she carries as she bows her head.

Skip then to Olbermann at 4:55, and this is where it gets really interesting in his discussion with Richard Wolf on Ms. Fruitfly. Wolf, also a writer for Newsweek, tears Palin a new one in his first several sentences. As you well know, Newsweek is hardly a lib publication.

Wolf also makes some really interesting observations about McCain's "budget freeze" (which is such a joke...).

Here is the video:



Good God.

Then, as if Wolf didn't dis this brainless wonder quite enough, blogger Pharyngula, a fine science blogger, had this to say:

I am appalled.

This idiot woman, this blind, shortsighted ignoramus, this pretentious clod, mocks basic research and the international research community. You damn well better believe that there is research going on in animal models — what does she expect, that scientists should mutagenize human mothers and chop up baby brains for this work? — and countries like France and Germany and England and Canada and China and India and others are all respected participants in these efforts.

I am rolling on the floor, at this point. Mercy!

And what is even funnier is that this is the most popular republican in the U.S.! This is the best of the best! Sorry, I am laughing so hard I am tearing up. And the most politically interesting thing about this is that Palin--Ms. Fruitfly--is the choice of the absolute whacks (read hard religious right and neo con types) to lead the party forward. Yes, you read that right.

This while the intellectual wing of the party (the very, very conservative--the moderates were driven out long ago) abandons ship in the middle of the Pacific because it is safer and makes more sense with nary a lifeboat in sight.

It doesn't get better than this. The GOP is perhaps now the GODp the Grand Old Dead Party.

This is what happens when you lead an idiot into 8 years of office, drive dissenters who may actually have a brain to walk the plank (thanks, Newt!), start wars with lies, destroy the economy, choose brainless eye candy (though I don't see it) turned "victim" for a vice president then try to defend her ignorance time and time again because you are "proud of her" (huh?), and whack the press over the head for sort of doing what they are supposed to thinking even that is way out of line.

If I had to write a list of things to do to destroy their campaign and the GOP simultaneously, I could not have come up with this stuff. This is the political Three Stooges in their Oscar-winning classic piano-moving comedy, "The Music Box" (about 4 min.):

And if this wasn't enough to just make my day, I got this from my musician beloved from Salt Lake City, Utah:

I have to tell you, I was at the [folks] yesterday & [dad] asked to make sure I was voting. He's INTO the election this year, & the life-long repub. is voting for Obama!! Palin scares him to death. Pretty cute.

It just doesn't get any better than that.

For All of You That Paid Attention During Science Class

... and especially for our own IT, thanks for all that you do to help in human health as researchers in your various capacities.

Photo Caption: Different species of fruit flies exhibit remarkably different patterns of wing decoration. At the top is the familiar Drosophila melanogaster, the workhorse model organism of genetics, which differs markedly from other fruit fly species. Exploring a single gene that controls pigment deployment in fruit flies, a group led by UW-Madison biologist Sean Carroll has found the molecular switches that control where the pigmentation is deployed on the wing. The finding explains how common genes can be controlled to produce the seemingly endless array of patterns, decoration and body architecture found in animals.
Photo: courtesy of Nicolas Gompel and Benjamin Prud'homme [italics mine]
Date: 2004

*****

Now, for those of you not in genetic or other fields of research, or who were not paying attention in high school science (or university, for that matter), let's take a quick look at the wonderful world of fruit fly research, WHY it needs to remain well funded, and why the vice president's new wardrobe should be auctioned off and the funds donated to fruit fly research.

A Little History on the Wee Fruit Fly and the Science of Genetics, Bioengineering, Molecular Biology etc.

Another indication of how closely we’re related to Drosophila is the discovery that about 60 percent of its genes can be found in humans and 70% of the genes known to cause human malignancy have been found to exist in similar form in the fruit fly. No wonder this little relative is one of the most studied organisms in biology.--from http://www.mdpsych.org/W02_gKlee.htm

--Thomas Hunt Morgan Cal Tech Nobel Laureate

Thomas Hunt Morgan won the Nobel Prize in Physiology or Medicine in 1933 for his chromosome theory of heredity. On the basis of experimental research with the fruit fly (Drosophila), he demonstrated that genes are linked in a series on chromosomes and that they determine identifiable, hereditary traits.

An embryologist by training, Morgan turned his attention to Drosophila in 1908. On the basis of fly-breeding experiments, he developed a hypothesis of sex-linked characteristics, which he theorized were part of the X chromosome of females. In 1928, he came to Cal Tech to organize work in biology. The most influential biologist in America at that time, Morgan pioneered the new science of genetics, the essential science for the future of biology. (...)

--Herman Muller, Nobel Laureate 1946. American geneticist Hermann Muller's work introduced the conceptual and empirical basis for modern molecular biology. Breeding huge numbers of the fruit fly Drosophila melanogaster, he demonstrated that exposure to X rays can cause mutations in genes and chromosomes of living cells, and warned that radiation could cause mutations in the human gene pool as well. His research won Muller the Nobel Prize for Physiology or Medicine in 1946.

--1995: Christine Nüsslein-Volhard: Co-winner [of the Nobel Prize] in physiology/medicine for her work on genetic control of early embryonic development in fruit flies (page to bottom), and as reported in the New York Times, October 10, 1995. Two of the three Nobel Laureate co-winners were Americans, one from Cal Tech, and one from Princeton.

There are many more prize winners whose basis of study were built on the foundations of fruit fly genetics.

So, Why Are These Studies Important?

These studies serve as the basis for understanding of the genetic cause of disease, for one. That includes the VERY disease Palin suddenly has an interest in, autism. Obviously, she didn't do her homework (as usual).

While the Palins have a child with Down's Syndrome, Palin's sister has a child with autism. Interestingly, research into autism includes a number of studies using (gasp!) fruit flies.

--What kind of genetic studies? The list of human-related topics fruit fly researchers are currently working on is surprisingly broad in scope: cancer; birth defects; development of the respiratory and circulatory systems; cardiovascular development and disease; taste, sight, smell and hearing; learning and memory; brain disease; sleep; drug abuse; aging; and diabetes.

Those were just the topics covered at the meeting. Missing from the list, but currently under investigation by scientists using fruit flies as a model, are eye development, circadian rhythms, blood cell development, malaria and Parkinson's disease, to name a few.

And of course, I need a little mini-rant, so here it is.

Do me a favor, Ms. Palin; just shut up. You have absolutely nothing to offer the United States on any issue and you are nothing more than an undereducated embarrassment.

Just because you, Ms. Palin, have little to no science training and certainly little respect for science and apparently none for college education--none of your adult children have attended college, your husband has no college education--doesn't mean that the rest of us share your anti-intellectualism.

As for the GOP, you can apologize to the US public and science community by auctioning off the embarrassing clothing of Ms. Palin and donating the funds to fruit fly research. It is painfully clear that the fruit fly has a much more important role to play in this world (and perhaps a better brain) than Ms. Palin